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提高数据标准,以促进脊髓损伤的翻译
Vanessa K Noonan1, Suzanne Humphreys2, Fin Biering-Sørensen3
1Praxis Spinal Cord Institute, Vancouver, BC, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Experimental neurology
|November 10, 2024
概括
脊髓损伤 (SCI) 数据标准是可用的和不断发展的. 采用可互操作标准,开放科学和先进分析,以创伤性脑损伤 (TBI) 研究为基础,可以改善SCI护理和研究成果.
科学领域:
- 神经学 神经学
- 生物医学信息学 生物医学信息学
- 数据科学数据科学数据科学
背景情况:
- 已建立的数据标准,如国际SCI数据集和NINDS常见数据元素,存在于脊髓损伤 (SCI).
- 创伤性脑损伤 (TBI) 领域为研究和临床护理利用数据提供了有价值的见解,特别是在并发损伤方面.
- 系统医学和大数据的进步需要多模式数据和开放科学原则来处理像SCI这样的复杂疾病.
研究的目的:
- 提供当前SCI数据标准的全面概述.
- 突出从TBI领域获得的经验教训,以利用数据进行研究和改善护理.
- 通过数据标准化和先进分析,讨论未来改善SCI研究和患者结果的机会.
主要方法:
- 审查现有的SCI数据标准和举措.
- 在TBI领域使用的数据共享和研究增强策略的分析.
- 在SCI的背景下探索系统医学,大数据和FAIR数据原则.
主要成果:
- 27个国际SCI数据集和NINDS共同数据元素的可用性促进了数据收集.
- 在TBI领域,有成功的数据共享和重复使用倡议,用于临床前和临床研究.
- 互操作性对于高级分析至关重要,例如SCI研究中的人工智能.
结论:
- 采用互操作标准,数据共享和开放科学对于推进SCI研究和护理至关重要.
- 利用先进的分析,包括人工智能,需要标准化和可访问的数据.
- 吸引具有实践经验的个人对于确保数据相关性和改善SCI患者的生活质量至关重要.
相关概念视频
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
02:07Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
02:07Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...