术后胺可能与脊椎手术后慢性阿片类药物使用者的静脉血栓栓塞有关
Rajkishen Narayanan1, Jonathan Dalton1, Robert J Oris1
1Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
World neurosurgery
|November 10, 2024
概括
手术后使用胺与脊椎手术后慢性阿片类药物使用者静脉血栓栓塞 (VTE) 的风险较高有关. 在慢性阿片类药物使用和VTE发生之间没有发现任何关联.
科学领域:
- 脊柱手术的结果 脊柱手术的结果
- 麻醉学 麻醉学
- 这是血管外科手术.
背景情况:
- 静脉血栓塞栓症 (VTE) 是脊椎手术后的一个重大风险.
- 慢性阿片类药物使用者往往需要替代止痛药,如围手术时的胺胺,用于耐火性疼痛.
- 在这个特定的患者群体中评估VTE风险至关重要.
研究的目的:
- 评估慢性阿片类药物使用与脊椎手术患者的静脉瘤之间的关联.
- 调查外科手术期间胺在慢性阿片类药物使用者VTE发展中的作用.
主要方法:
- 使用结构化查询语言进行回顾性研究,以识别脊椎手术后的VTE病例 (2017-2021年).
- 分析了患者数据,包括通过处方药监测计划使用阿片类药物.
- 慢性阿片类药物使用者被定义为处方的频率和持续时间.
主要成果:
- 总共分析了322名患者,其中29例确诊VTE病例.
- 静脉瘤组的住院时间明显长,Elixhauser并发症指数得分更高.
- 在慢性阿片类药物使用者中,术后使用胺与VTE显著相关 (P=0.034).
结论:
- 在脊椎手术后,慢性阿片类药物使用和VTE之间没有发现任何联系.
- 在外科手术期间注入胺与静脉瘤风险增加有显著的关联.
- 需要进一步的研究,以了解胺和其他新型止痛药在脊柱手术患者的风险.
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