对通用溶剂二甲基硫氧化物毒理作用的代谢学分析
Sazal Kumar1, Rafiquel Islam2, Wayne O'Connor3
1School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
|November 10, 2024
概括
低剂量的二甲基硫氧化物 (DMSO) 显著改变了的新陈代谢,影响了能量,透平衡和氧化应激. 这些影响因性别和组织而异,混研究,并需要在实验中仔细控制溶剂.
科学领域:
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
- 代谢学 代谢学 代谢学
背景情况:
- 甲基二硫氧化物 (DMSO) 是一种常见的溶剂,在低度下被认为是安全的.
- 新出现的证据表明,低剂量的DMSO可以影响细胞生物化学.
- 了解DMSO微妙的影响对于准确的生态毒理学研究至关重要.
研究的目的:
- 为了评估低度的DMSO (v/v 0.0002%) 对悉尼岩的毒性, Saccostrea glomerata.
- 评估DMSO对不同组织和性别的代谢概况的影响.
- 确定DMSO暴露对生态毒理学实验设计的影响.
主要方法:
- 在7天内将悉尼石暴露在0.0002%的DMSO中.
- 使用代谢学分析组织代谢物 (消化腺,性腺) 的变化.
- 进行途径影响分析,以确定受影响的生物过程.
主要成果:
- 在女性消化腺 (74%) 和性腺 (43%) 和男性消化腺 (29%) 中观察到代谢物显著变化.
- DMSO暴露改变了能量代谢,扰乱了透平衡,并在中诱导了氧化应激.
- 代谢变化在性别和组织之间有所不同,女性显示出更大的破坏.
结论:
- 0.0002%的DMSO显著影响的新陈代谢,影响能量路径和应激反应.
- 跨性别和组织的DMSO不均的影响可能会混比较代谢学研究.
- 建议在涉及DMSO的实验中使用水和溶剂对照,以确保准确的结果.
相关概念视频
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