具有pH敏感性的氨基化奇托/甲基纤维素/氨基化石墨烯氧化物涂层的复合微珠,用于有效封装和持续释放5-甲
Ahmed M Omer1, Mahmoud A Elmeligy2, Eman M Abd El-Monaem3
1Polymer Institute of the Slovak Academy of Sciences, Dúbravská Cesta 9, 845 41 Bratislava, Slovakia; Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), P. O. Box: 21934, New Borg El-Arab City, Alexandria, Egypt.
International journal of biological macromolecules
|November 10, 2024
概括
这项研究开发了使用氨基化石墨烯氧化物和奇托来增强口服抗癌药物递送的新型pH敏感微珠. 复合微珠改善了5-甲封装和持续释放,显示了结肠癌治疗的前景.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 对pH敏感的微珠非常适合口服药物输送,但面临着低封装度和稳定性差等挑战.
- 开发先进的载体对于有效的口服服用抗癌药物如5-甲 (5-FU) 至关重要.
研究的目的:
- 设计pH敏感的涂层复合材料微珠,以改善5-甲封装和持续的口服输送.
- 为了克服抗癌药物管理中的传统pH敏感微珠的局限性.
主要方法:
- 制造与氨基化石墨烯氧化物 (AmGO) 集成的碳素甲基纤维素 (CMC) 微珠,并涂有氨基化基 (AmCs).
- 使用FTIR,SEM,XRD,XPS,TGA,泽塔电位和机械测试进行表征.
- 评价pH敏感度,水吸收,5-FU封装效率和体外释放动力学.
主要成果:
- AmCs@CMC@AmGO复合微珠表现出增强的机械强度 (Young的模量为35.99N/mm2) 和紧的结构.
- 5-FU的封装效率达到86.4%,明显高于纯CMC微珠 (47%).
- 在Fickian扩散动力学 (Peppas-Sahlin模型) 之后,通过减少爆发释放实现了5-FU的持续释放.
结论:
- 开发的pH敏感复合微珠为口服5-FU输送提供了卓越的性能.
- 这些微珠显示出改善的生物降解性,对正常细胞无毒性,对癌细胞有针对性的毒性.
- 这种新型配方显示出有效和更安全的口服抗癌药物输送系统的巨大潜力.
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