膝关节骨关节炎患者分子内型的纵向稳定性
Monica T Hannani1, Christian S Thudium2, Alfred C Gellhorn3
1Nordic Bioscience, Herlev, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Osteoarthritis and cartilage
|November 10, 2024
概括
超过一半的膝关节骨关节炎患者随着时间的推移显示出稳定的分子内型. 这一发现支持在膝关节骨关节炎的临床试验中使用基于生物标志物的内型鉴定.
科学领域:
- 生物标志物的发现和验证.
- 分子诊断学 分子诊断学
- 骨关节炎的研究研究.
背景情况:
- 膝关节关节炎 (KOA) 是一种异质性疾病.
- 基于生物标志物的分子内型鉴定提供了一个有前途的方法来分层KOA患者.
- 这些内型的纵向稳定性对于临床应用至关重要.
研究的目的:
- 在膝关节骨关节炎 (KOA) 患者中评估基于生物标志物的分子内型的纵向稳定性.
- 在一个独立的KOA队列中验证这些发现.
- 评估内型化在试验环境中的临床适用性.
主要方法:
- 在APPROACH队列中的295名KOA参与者中,纵向测量了19个生物标志物.
- 在6个月,12个月和24个月,K-means集群确定了结构损伤,炎症和低组织周转率的内型.
- 评估了内型稳定性,并比较了稳定与不稳定内型的特征.
主要成果:
- 总体呈现了55%的纵向内型稳定性 (Fleiss' Kappa = 0.53).
- 稳定性因内型而异:结构损伤 (59%),炎症 (54%) 和低组织周转率 (50%).
- 不稳定的内型从第一次访问开始就表现出多种内型的特征.
结论:
- 超过一半的KOA参与者表现出纵向稳定的分子内型.
- 这种稳定性支持基于生物标志物的内型鉴定在膝关节骨关节炎的临床实用性.
- 结果在独立的KOA群体中是一致的,加强了临床试验中的适用性.
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