怀孕中的性结肠炎:一项日本多中心队列研究,重点关注它们的相互影响
Yuichi Shimodate1, Akiko Shiotani2, Ken-Ichi Tarumi3
1Department of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, Kurashiki Central Hospital, Japan.
Internal medicine (Tokyo, Japan)
|November 10, 2024
概括
在怀孕期间持续服用性结肠炎 (UC) 药物至关重要,因为停止治疗会显著增加UC复发的风险. 谨慎管理UC疗法对于健康的妊娠结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 产科 产科 产科 产科 产科
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 患有UC的女性怀孕需要仔细考虑疾病活动和治疗.
- 了解UC和怀孕之间的相互作用对于最佳的患者护理至关重要.
研究的目的:
- 在怀孕期间调查性结肠炎 (UC) 的临床过程.
- 评估UC对怀孕的影响,反之亦然.
- 评估药物管理对怀孕期间UC复发率的影响.
主要方法:
- 对58名UC患者和73名怀孕患者的医疗记录进行了回顾性审查.
- 包括3名怀孕期间新发性UC患者.
- 收集关于UC复发率,药物使用,治疗和怀孕/新生儿结局的数据.
主要成果:
- 78%的患者在受孕时UC处于缓解状态.
- 怀孕期间复发率为27.3%,主要发生在第二和第三季度.
- 停止使用UC药物导致50%的复发率,明显高于继续使用药物的20.5% (p=0.016).
- 产后UC复发发生在2个月内26.1%的患者中.
- 在23.3%的病例中观察到怀孕,分娩或新生儿异常.
- 在怀孕期间新发性UC在3个病例中有2个是严重的,但怀孕没有发生任何事件.
结论:
- 在大多数患有UC的患者中,妊娠进展通常是无事件的.
- 停止使用UC药物显著增加了疾病复发的风险.
- 在怀孕期间适当的UC医疗管理对于有利的结果至关重要.
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