在mRNA后急性严重结肠炎 冠状病毒疾病 2019年疫苗接种
Akira Nakanishi1, Sakuma Takahashi1, Tomoki Inaba1
1Department of Gastroenterology, Kagawa Prefectural Central Hospital, Japan.
Internal medicine (Tokyo, Japan)
|November 10, 2024
概括
严重的急性结肠炎是一种罕见的不良事件,可在COVID-19疫苗接种后发生. 这一案例凸显了考虑2019年冠状病毒病 (COVID-19) 疫苗接种作为严重胃肠道症状的潜在触发因素的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
- 免疫学 免疫学 免疫学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病需要快速开发疫苗.
- 针对COVID-19的mRNA疫苗已经证明了其高效和安全性.
- 接种疫苗后的罕见不良事件需要彻底调查.
研究的目的:
- 在mRNA COVID-19疫苗接种后报告严重急性结肠炎病例.
- 描述这种不良事件的临床表现,诊断结果和管理.
- 提高临床医生对这种潜在并发症的认识.
主要方法:
- 一个74岁的老妇人的病例报告.
- 临床评估包括实验室检测,增强对比度的计算机断层扫描,半导体镜和全结肠镜.
- 对普得尼索隆治疗的反应的评估.
主要成果:
- 患者在她第六次mRNACOVID-19疫苗注射后的第二天出现了急性严重结肠炎.
- 症状包括血淋淋的腹,腹痛,发烧,白细胞症和高C反应蛋白.
- 图像和内镜检查结果证实了带有粘膜脱落的广泛性结肠炎.
- 随着普雷迪尼索隆治疗,观察到快速改善,并且发生了粘膜愈合.
结论:
- 严重的急性结肠炎是mRNA COVID-19疫苗接种后的潜在,尽管罕见的不良事件.
- 早期识别和适当的管理,包括皮质类固醇治疗,至关重要.
- 临床医生必须对接种疫苗后的胃肠道并发症保持警.
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