肌源性古典内分类大麻素,它们的目标和活动
Olga P Balezina1, Ekaterina O Tarasova2, Polina O Bogacheva1
1Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Biochemistry. Biokhimiia
|November 10, 2024
概括
本综述探讨了肌内可纳素 (myoendocannabinoid) (myoEC) 池,重点关注骨肌中的2-阿拉基多诺伊尔甘油醇 (2-AG) 和阿拉基多诺伊尔乙醇胺 (AEA). 这些myoECs影响肌肉功能,能量,并可能导致运动引起的情绪变化.
科学领域:
- 身体生理学 身体生理学
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 内体大麻素 (ECs) 是关键的信号分子.
- 经典的ECs,2-arachidonoylglycerol (2-AG) 和arachidonoyl ethanolamide (AEA),是在骨肌中合成和降解的.
- 人们越来越认识到肌内分泌大麻素 (myoendocannabinoid,myoEC) 池的作用.
研究的目的:
- 审查myoEC池的合成,降解和特定作用.
- 检查myoECs对骨肌肉,运动突触和整个生物体的影响.
- 讨论myoECs在能量代谢,肌肉收缩和神经递质释放中的作用.
主要方法:
- 关于myoEC合成和降解研究的文献综述.
- 在肌肉,突触和系统层面分析myoECs的影响.
- 讨论关于运动生理学和心理生理学条件中的myoECs的当前假设.
主要成果:
- MyoECs (2-AG和AEA) 对肌肉能量交换和收缩活动产生积极影响.
- 肌肉收缩调节了参与myoEC合成和降解的酶的平衡.
- MyoECs影响运动突触中的神经递质分泌.
结论:
- 肌肌电池在调节肌肉功能和能量平衡方面发挥着重要的,但往往被低估的作用.
- MyoECs可能有助于运动诱导的高兴感 ("跑步者的高") 并调节疼痛和压力反应.
- 这次审查强调了myoEC池的独立监管能力,与神经性EC不同.
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