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Updated: Jun 7, 2025

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications
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一个深度神经网络模型,用于将药房实践出版物分类为研究领域

Samuel O Adeosun1, Afua B Faibille2, Aisha N Qadir2

  • 1Department of Clinical Sciences, High Point University One University Parkway, High Point, NC, 27268, USA; Fred Wilson School of Pharmacy, High Point University One University Parkway, High Point, NC, 27268, USA.

Research in social & administrative pharmacy : RSAP
|November 10, 2024
PubMed
概括

一个新的药学实践研究领域分类器 (PPRDC) 准确地将教师出版物分为四个领域,在文献分析中表现优于通用大型语言模型 (gpLLMs).

关键词:
人工智能的人工智能是人工智能.贝尔特 (BERT) 公司"分类器"是指分类器.格拉纳达声明 格拉纳达声明大型语言模型.药房实践的做法 在药房实践.研究领域 研究领域

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Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
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Model Approaches for Pharmacokinetic Data: Compartment Models

Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
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Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
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