体重调整腰部指数与家族高胆固醇血症之间的关联:一个横截面研究
Xuan Lyu1, Xuanxuan Ren2, Weiqing Zhang1
1Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
BMC cardiovascular disorders
|November 10, 2024
概括
体重调整后腰部指数 (WWI) 与家族高胆固醇血症 (FH) 的更高可能性有关. 较高的WWI水平与增加的FH患病率相关,这表明WWI是FH风险的潜在指标.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致高的LDL胆固醇.
- 肥胖是一个日益关注的问题,与心血管疾病有关.
- 需要新的肥胖指标来评估心脏代谢风险.
研究的目的:
- 调查体重调整腰部指数 (WWI) 和家族高胆固醇血症 (FH) 之间的关联.
- 确定第一次世界大战是否可以作为FH患病率的预测指标.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2017-2020) 3698 名参与者的横截面数据的分析.
- 使用多变量逻辑回归和平滑曲线拟合来评估第一次世界大战和FH之间的相关性.
- 进行了子组分析和相互作用测试,以探索重要的关联.
主要成果:
- FH的总体可能患病率为5.43%,随着第一次世界大战的第三者增加.
- 在第一次世界大战的最高阶段的个人,FH的可能性明显更高 (OR=4.60).
- 在第一次世界大战和早期动脉样硬化心血管疾病 (ASCVD) 的个人/家族病史之间发现了关于FH患病率的显著相互作用.
结论:
- 体重调整腰部指数 (WWI) 和家族高胆固醇血症 (FH) 之间存在非线性正相关性.
- WWI可能为预防和管理FH提供新的见解.
- 这项研究强调了第一次世界大战在评估与FH有关的心血管风险方面的重要性.
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