泰戈普拉赞-阿莫西西林双疗法用于杆菌根除:在中国福建的一项前性,随机的多中心研究
Xueyan Lin1,2,3, Huping Huang1,2,3, Yijuan Liu4
1Department of Gastroenterology, The Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China.
Helicobacter
|November 10, 2024
概括
泰戈普拉桑-阿莫西西林双疗法显示出高的Helicobacter pylori根除率,与斯木四重疗法相比. 这种双重治疗提供了更好的安全性,缓解症状和成本效益,对肠道微生物群有暂时的影响.
科学领域:
- 胃肠病学和肝病学
- 传染性疾病 传染性疾病
- 药理学 药理学 是一个学科.
背景情况:
- 杆菌 (H. pylori) 感染仍然是一个重大的全球健康问题,需要有效的根除策略.
- 有限的研究存在于特戈普拉桑-阿莫西西林 (TA) 双重治疗H. pylori根除的疗效和安全性.
- 这项研究解决了评估TA双疗法不同剂量的必要性.
研究的目的:
- 评估不同剂量的泰戈普拉桑-阿莫西西林 (TA) 双重治疗对H.pylori根除的有效性和安全性.
- 为了比较TA双疗法与木四重疗法 (BQT) 的根除率,不良反应和临床症状缓解.
- 探索TA治疗对肠道微生物群的影响,并进行成本效益分析.
主要方法:
- 一项前性,随机的,开放的,多中心的研究,涉及321名H. pylori感染的患者.
- 患者被随机分配,接受双重治疗方案 (TA-qd或TA-bid) 的双重治疗方案 (TA-qd或TA-bid) 之一或双重治疗方案 (BQT).
- 主要结局是根除率的非劣势;次要结局包括不良反应和症状缓解;探索性结局侧重于肠道微生物群和成本效益.
主要成果:
- 与BQT相比,Tegoprazan-阿莫西西林双疗法 (TA-qd和TA-bid) 在治疗意图,修改治疗意图和每条协议分析 (>90%的根除) 中实现了非劣势的H. pylori根除率.
- 与BQT (27.18%) 相比,TA双疗法表现出明显较低的不良反应发生率 (13.33-14.56%).
- 临床症状的完全缓解在TA组 (65.71-68.93%) 与BQT (36.89%) 相比显著更高;TA治疗对肠道微生物群产生轻微,可逆的影响.
结论:
- 与BQT相比,泰戈普拉桑-阿莫西西林双疗法显示出令人满意的H. pylori根除率,优越的安全性概况和增强的临床症状缓解.
- 这两种TA双重治疗方案都有效且耐受良好,对肠道微生物群的影响最小且短暂.
- 与较低剂量的泰戈普拉赞 (TA-qd) 结合的TA双疗法呈现出更好的成本效益,使其成为H. pylori根除的潜在有利选择.
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