22q11.2删除综合征的成年人的认知,适应和日常生活功能
Claudia Vingerhoets1, Julia Ruiz-Fernandez2, Emma von Scheibler3
1Department of Psychiatry and Neuropsychology, MHeNs, Maastricht University, Maastricht, The Netherlands; and Advisium, 's Heeren Loo Zorggroep, Amersfoort, The Netherlands.
BJPsych open
|November 11, 2024
概括
患有22q11.2删除综合征 (22q11.2DS) 的成年人经常经历认知和适应功能低下. 这项研究强调,需要更好地了解这一群体的长期结果.
科学领域:
- 遗传学和人类发展
- 神经发育障碍 神经发育障碍
- 临床心理学 临床心理学
背景情况:
- 22q11.2删除综合征 (22q11.2DS) 与认知问题和精神病理学有关.
- 大多数研究都集中在儿童身上,对成人结果的研究不足.
- 了解成年人的功能是至关重要的,因为他们代表了大多数受影响的个体.
研究的目的:
- 评估22q11.2DS的成年人的认知能力,适应性功能和日常生活结果.
- 为了确定影响这个群体适应性功能的因素.
主要方法:
- 对250名讲荷兰语的成年人 (16-69岁) 的回顾性分析,22q11.2DS.
- 使用韦克斯勒成人智商量表 (Wechsler Adult Intelligence Scale) 评估全尺度智商 (FSIQ).
- 评估适应性行为 (维尼兰适应性行为量表II) 和功能性结果 (婚姻,生活,工作状态).
主要成果:
- 显著的大多数 (65%) 显示适应性功能较低.
- 超过一半 (56%) 在智力障碍水平上运行,与儿科发现不同.
- 男性性别,较低的FSIQ和自闭症谱系障碍预测了较差的适应性功能.
结论:
- 低认知和适应功能在22q11.2DS的成年人中普遍存在.
- 需要进一步进行纵向研究,特别是在老年人 (>40岁) 中.
- 调查与身体和精神伴随性疾病的相互作用对于综合护理至关重要.
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