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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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基于Connectome的预测建模老化,整体认知功能和记忆性能.

Yi Gu1, Lianghu Guo1, Xinyi Cai1

  • 1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.

The European journal of neuroscience
|November 11, 2024
PubMed
概括

大脑连接组模式可以预测健康成年人的衰老和智商 (IQ). 虽然大脑连接体显示出与记忆系数 (MQ) 的弱联系,但它调解了年龄-认知关系,这表明它是认知健康的保护机制.

关键词:
年龄化的衰老.大脑的连接性大脑的连接性基于 connectome 的预测建模.情报系数 智力系数记忆的分数 记忆的分数休息状态的fMRI.

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科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学
  • 医疗成像医学成像

背景情况:

  • 休息状态功能磁共振成像 (rs-fMRI) 和大脑连接体分析提供了对大脑衰老和认知功能的洞察.
  • 之前的研究分别检查了大脑连接组与年龄,全球认知和记忆的关联.
  • 很少有研究同时整合了年龄,整体认知和记忆表现的预测.

研究的目的:

  • 为了确定大脑连接体标记器预测年龄,智商 (IQ) 和记忆率 (MQ) 在健康的老龄化队列.
  • 探索大脑连接,衰老和认知功能之间的复杂相互关系.
  • 研究大脑连接体在年龄和认知功能之间的关系中的调解作用.

主要方法:

  • 采用了基于数据的方法,对来自多中心,正常衰老队列 (n=313) 的rs-fMRI数据进行了数据驱动.
  • 应用预测建模来评估大脑连接组预测年龄,智商和MQ的能力.
  • 进行了调解分析,以检查大脑连接体在年龄认知联系中的作用.

主要成果:

  • 大脑连接组成功预测了时间年龄和智商.
  • 大脑连接体和MQ之间的关联被发现是弱的.
  • 涉及轨道前皮层的连接性与年龄和智商都有显著的关联.

结论:

  • 大脑连接体是衰老和整体认知功能 (IQ) 的重要预测因素.
  • 大脑连接体可能起到调解作用,在健康的衰老过程中为认知功能提供保护机制.
  • 这些发现突出了维持整个生命周期的认知健康的潜在神经相关性.