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心房动基质和左心房功能受损:心脏MRI研究

Yaacoub Chahine¹, Nadia Chamoun¹, Ahmad Kassar¹

¹Division of Cardiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

|November 11, 2024

概括

左心房纤维化和心表脂肪组织 (EAT) 与心房动 (AF) 患者的左心房功能降低有关. 心脏磁共振成像 (CMR) 揭示了这些关联,突出了它们在AF基质中的作用.

科学领域:

心血管成像 - 心血管成像
心脏电生理学心脏电生理学
医学成像分析医学成像分析

背景情况:

心房动 (AF) 与左心房 (LA) 的结构和纤维化重塑有关.
心脂肪组织 (EAT) 越来越多地参与心房电力改造和AF病变.
了解LA纤维化,EAT和LA功能之间的相互作用对于AF管理至关重要.

研究的目的:

调查LA纤维化和EAT与LA菌株和功能之间的关联.
使用心脏磁共振成像 (CMR) 进行AF患者的定量评估.

主要方法:

一百一名AF患者在鼻节律中接受了前切除CMR.
通过晚期加多增强评估LA纤维化;使用迪克森序列量化LA EAT.
特征跟踪分析了全球纵向应变 (GLS) 组件;LA排空分数和体积从电影序列中测量.

主要成果:

LA纤维化与所有三个GLS组件 (GLRS,GLCdS,GLCtS) 和LA排空分数负相关.
LA EAT与GLCdS呈负相关性,与LA排空分数没有显著相关性.
无论是LA纤维化还是EAT,都与增加的LA体积有正相关.

结论:

LA纤维化和EAT与LA功能受损有显著的关联,这是由菌株分析证明的.
这些发现强调了LA纤维化和EAT作为AF基质的关键贡献者的作用.
CMR成像为LA纤维化和AF中EAT的结构和功能后果提供了宝贵的见解.

关键词:

心房动是一种心房动.心脏磁力共振成像 (MRI)胸前脂肪组织的副心脏脂肪组织.纤维化纤维化纤维化左心房的体积是左心房.压力应变是一种压力.

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