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多个omics揭示了微生物群-肠-大脑轴和内动脉瘤破裂之间的联系

Hongyu Xu^1,2, Qiangqiang Zhou^1,2, Ziyue Xu^1,2

¹Brain Research Center, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.

|November 11, 2024

概括

肠道功能失调,或肠道细菌的不平衡,与破裂的内动脉瘤 (RIA) 有关. 这项研究确定了与RIA相关的特定肠道微生物和代谢变化,为风险评估提供了潜在的生物标志物.

科学领域:

神经学神经学
胃肠病学胃肠病学
微生物学微生物学

背景情况:

内动脉瘤 (IAs) 涉及动脉壁扩张,破裂导致危及生命的脑下关节下出血 (SAH).
新兴研究表明肠道失调和IA发展之间存在联系,但其在IA破裂中的作用尚不清楚.

研究的目的:

调查肠道微生物群,代谢物和内动脉瘤破裂状态之间的关联.
基于肠道微生物组和代谢数据,开发破裂内动脉瘤 (RIA) 的风险评估模型.

主要方法:

分析了124个便样本用于微生物组学和160个用于代谢组学,使用发现和验证套件.
在RIA患者中识别不同的肠道微生物群和代谢物.
综合性分析以探索代谢途径,肠道微生物群和IA破裂之间的联系.

主要成果:

在RIA患者中发现了不同的肠道微生物群和代谢物.
为RIAs开发了一种优越的风险评估模型.
被破坏的不和脂肪酸和必需氨基酸代谢途径与IA破裂有显著的联系,由肠道微生物群的改变驱动.

结论:

肠道微生物群失调是IA破裂的潜在危险因素.
肠-大脑轴可能在IA破裂的发病过程中发挥作用.
确定肠道微生物和代谢特征可以作为评估IA破裂风险的潜在生物标志物.

关键词:

临床神经科学临床神经科学微生物组是一个微生物组.

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