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在活跃的虫病中,循环中的2组先天性淋巴细胞表达激活标志物和相关的三酶AB1水平的升高

Juan-Felipe López^1,2, Josefina Zakzuk², Pattraporn Satitsuksanoa¹

¹Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Frontiers in immunology

|November 11, 2024

概括

阿斯卡里斯感染激活2组先天性淋巴细胞 (ILC2) 并增加酶α/β1 (TPSAB1) 水平,可能有助于2型免疫反应. 这项研究调查了ILC2在阿斯卡里斯感染中的作用.

科学领域:

免疫学免疫学免疫学
寄生虫学的寄生虫学
传染性疾病传染性疾病

背景情况:

Ascaris lumbricoides感染是一种常见的土壤传播的虫病.
对阿斯卡里斯的IgE反应可能会增加喘和阿托皮的风险.
在人类虫感染中,2组先天性淋巴细胞 (ILC2) 的作用尚不清楚.

研究的目的:

调查和描述阿斯卡里斯 lumbricoides感染对循环ILCs的影响.
探索阿斯卡里斯感染,ILC2和相关免疫标记物之间的关联.

主要方法:

研究来自特有地区的非感染者 (NI) 和阿斯卡里斯感染者 (AI).
使用Kato-Katz检测寄生虫,ELISA检测抗体,以及用于ILC子集和激活标记物的流细胞计.
采用近距离延伸试验 (PEA) 来识别与感染相关的血蛋白.

主要成果:

在NI和AI组之间,总ILC,ILC1,ILC2或ILC3频率没有显著差异.
对ABA-1敏感的AI受试者显示出更高的ILC2频率和计数.
在AI受试者中观察到激活ILC2 (CD25+,CD69+,TSLPR+) 的频率增加.
卵子负担与CD69+ ILC2频率正相关.
在AI组中发现TPSAB1和其他蛋白质的水平升高.
TPSAB1水平与激活的ILC2,卵子负担和对抗阿斯卡里斯的IGE相关.

结论:

阿斯卡里斯感染与增加的ILC2激活标记物和TPSAB1表达有关.
这些发现表明,在虫感染中,可能会对2型免疫反应做出贡献.

关键词:

在 IgE 中,IgE 是试酶AB1 AB1 试酶AB1 AB1 试酶AB1 AB1 这种病叫做ascariasis.头盔的头盔是什么意思免疫调节免疫调节天生的淋巴细胞是先天性淋巴细胞.第二种类型的免疫.

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