在两个案例中,Belzutifan成功准了体质VHL变化的变化
Bicky Thapa1, Aditya Shreenivas1, Kathryn Bylow1
1Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Journal of immunotherapy and precision oncology
|November 11, 2024
概括
贝尔祖提凡是一种HIF-2α抑制剂,对具有VHL突变的晚期细胞癌 (RCC) 患者表现有前途. 两个不耐药的转移性RCC病例实现了长期的部分缓解,这表明有针对性治疗的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 清细胞细胞癌 (RCC) 的发病过程涉及VHL瘤抑制基因的改变,导致缺氧诱导因子通路的激活.
- 目前的治疗方法,如免疫检查点抑制剂和VEGF抑制剂,对转移性RCC的长期疗效有限,疾病进展频繁.
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