长期COVID中的重叠条件在一个多站点学术中心
Stephanie L Grach1, Daniel V Dudenkov2, Beth Pollack3
1Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States.
Frontiers in neurology
|November 11, 2024
概括
长期COVID患者经常报告新的或恶化的并发症,包括疼痛,神经问题和睡眠障碍. 这项研究强调了长期COVID和ME/CFS等疾病之间存在显著的重叠.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 后病毒综合征 后病毒综合征
背景情况:
- 在COVID-19后持续的症状被称为长期COVID (LC).
- 在LC患者中发现新的或恶化的并发症对于了解该综合征至关重要.
研究的目的:
- 识别长期COVID患者中新出现或恶化的新型,自我报告的并发症.
- 调查长期COVID和肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS),通用性关节高移动性 (GJH) 和静止不耐受性之间的重叠.
主要方法:
- 一项涉及732名被诊断患有LC的患者和一组没有LC的SARS-CoV-2患者的对照组的比较研究.
- 调查问卷用于评估新的/恶化的并发症,并查ME/CFS,GJH和静态不耐受性.
- 在LC患者中,应答率为33.7% (n=247),在对照组中为50% (n=40).
主要成果:
- 与对照人群相比,LC患者报告了新的/恶化的疼痛 (94.4%),神经 (92.4%),睡眠 (82.8%),皮肤 (69.8%) 和泌尿生殖系统 (60.6%) 问题的明显更高的患病率.
- 58%的LC患者对ME/CFS进行了查,27%的GJH呈阳性,平均正静性不耐受得分为4.0,所有这些都明显高于对照组.
- 大多数患有ME/CFS的LC患者是女性 (77%).
结论:
- 在长期COVID患者中,SARS-CoV-2感染与多种类型的并发症的增加有关.
- 这些发现支持长期COVID,ME/CFS,GJH和静态不耐受性之间存在显著的重叠.
- 需要进一步研究这些重叠条件的病理生理学,临床和研究含义.
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