基于纳米粒子的药物输送系统增强了对认知缺陷的治疗
Gofarana Wilar1,2, Cecep Suhandi2, Nasrul Wathoni2
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
International journal of nanomedicine
|November 11, 2024
概括
纳米颗粒药物输送提供了一个有前途的方法来治疗认知障碍,通过提高药物溶解度和大脑透度. 需要进一步的临床试验来验证这些系统对神经疾病的疗效.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经系统疾病,特别是认知障碍,对有效向中枢神经系统 (CNS) 输送药物提出了重大挑战.
- 常规药物经常因溶解性差以及穿越血脑屏障 (BBB) 的能力有限而扎.
研究的目的:
- 审查基于纳米颗粒的药物输送系统在增强针对认知障碍的疗法方面的潜力.
- 总结纳米颗粒用于中枢神经系统药物输送的类型,特性和有效性.
主要方法:
- 用于认知增强的纳米粒子类型 (聚合物,基于脂质,金属/无机) 的文献综述.
- 对中枢神经系统输送至关重要的纳米粒子特征的分析:大小,电荷,形态,负载能力和释放动力学.
- 检查诸如涂层剂和连接体结合等修饰物,以改善大脑细胞吸收.
主要成果:
- 纳米粒子提高药物溶解性,BBB透,并使神经治疗的持续释放成为可能.
- 聚合物,基于脂质和金属/无机纳米颗粒对认知增强具有明显的优势和局限性.
- 有证据表明,纳米粒子系统改善了认知功能,减少了氧化应激和抗炎作用.
结论:
- 纳米颗粒药物输送系统显示出治疗认知障碍和其他神经疾病的巨大潜力.
- 精心定制纳米粒子特征对于成功的中枢神经系统药物输送至关重要.
- 由于缺乏临床试验,需要进一步的研究来验证这些先进的输送系统的治疗疗效.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
98
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
98
01:22Alzheimer's Disease: Treatment
165
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
165
01:29Drug Delivery: Parenteral Route
425
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
425
01:22Drug Delivery: Miscellaneous Routes
328
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
328
01:21Factors Affecting Drug Response: Overview
1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
01:28Drug Therapy
39
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
39