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新诊断的肺癌中大脑转移:流行病学和条件生存

Chong Yuan¹, Huandong Zheng¹

¹Department of Cardiothoracic Surgery, Yuyao People's Hospital, Yuyao, China.

Translational cancer research

|November 11, 2024

概括

大脑转移的肺癌 (LCBM) 影响每10万人中有5.82人. 一个新的名图模型为LCBM患者提供了个性化的生存预测.

科学领域:

在瘤学瘤学.
神经学神经学
流行病学流行病学

背景情况:

大脑转移是非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 的常见并发症.
脑转移的肺癌 (LCBM) 显著增加了患者的发病率和死亡率.
了解LCBM发生率和生存率对于患者护理至关重要.

研究的目的:

确定在美国发生的脑转移性肺癌 (LCBM) 的发病率和存活率.
为LCBM患者开发一个动态的预后模型.

主要方法:

从SEER数据库 (2010-2015) 中对9,212名LCBM患者的分析.
使用卡普兰-梅尔和CS公式计算发病率,相对存活率和条件存活率 (CS).
通过LASSO回归和Cox回归进行预后因子识别,从而获得基于CS的名图.

主要成果:

经年龄调整后的LCBM发病率为每10万人中5.82,略有下降.
随着年龄的增加,生存率下降.
根据生存时间 (1-4年) 的计算,5年条件生存率从3%提高到73%.
关键预测因素包括年龄,性别,种族,瘤特征和治疗方式.

结论:

该研究提供了对LCBM的流行病学见解.
开发了一种基于CS的新型名ogram,用于动态和个性化的预后预测.
诺米图为LCBM患者提供临床上有价值的实时生存估计.

关键词:

肺癌与大脑转移 (LCBM) 的肺癌监测,流行病学和最终结果 (SEER)发生率的发生率.这个名字是名ogramogram.幸存率幸存率生存率

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