对MSMO1的上调与宫癌患者的生存率低下有关
Jing Zou1, Sha Liu1, Jian Long1
1Department of Oncology, Jingzhou Hospital, Yangtze University, Jingzhou, China.
Translational cancer research
|November 11, 2024
概括
甲基胆固醇单氧酶1 (MSMO1) 在宫癌中升高,并与较差的患者结局有关. 这一发现表明MSMO1可能是宫癌进展和预后的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 甲基胆固醇单氧酶1 (MSMO1) 在胆固醇生物合成中发挥作用.
- MSMO1与各种瘤的进展有关.
- MSMO1与子宫癌之间的关联仍然未被探索.
研究的目的:
- 为了研究MSMO1在宫癌中的表达模式.
- 确定MSMO1表达和宫癌患者的临床特征之间的相关性.
主要方法:
- 在306个宫癌组织和13个非瘤组织中分析MSMO1表达.
- 威尔科克森等级总和测试用于表达式比较.
- 预后相关性的单变量和多变量回归分析.
- 卡普兰-梅尔生存分析.
- 蛋白相互作用和T细胞透分析.
主要成果:
- 与非瘤组织相比,MSMO1表达在宫癌组织中显著上调 (P<0.001).
- 较高的MSMO1表达与晚期疾病阶段 (III-IV阶段) 和不完整的治疗反应 (P=0.04,P<0.001) 相相关.
- 增加的MSMO1与显著降低整体存活率 (OS),疾病特异性存活率 (DSS) 和无进展存活率 (PFS) (P≤0.004) 相关.
- 高MSMO1表达被确定为OS,DSS和PFS在宫平细胞癌 (CESC) 的独立风险因素 (HR>1.9,P≤0.01).
结论:
- 在宫癌中,MSMO1显著过度表达.
- 增加MSMO1表达与不良的临床特征和CESC的不良预后相关.
- MSMO1 作为宫癌的潜在独立预后生物标志物.
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Receptor Downregulation in MVBs
2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.0K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Induced Pluripotent Stem Cells
3.9K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
3.9K


