相关实验视频
Updated: Jun 7, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
383
在肝细胞癌中SKA2及其ceRNA网络的致癌作用,基于综合分析
Wanxue Hu1, Xiaoyi Hu2, Yongchao Zhu1
1Department of Clinical Laboratory, Hua County People's Hospital, Anyang, China.
Translational cancer research
|November 11, 2024
概括
在肝细胞癌 (HCC) 中高SKA2表达与生存率差和晚期瘤相相关. SKA2充当竞争的内源RNA (ceRNA),通过特定的微RNA和长非编码RNA相互作用影响HCC进展.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 遗传变化驱动癌症的发展和进展.
- SKA2 (螺旋体和动态体相关复杂子单元2) 对于线粒细胞调节至关重要.
- 在肝细胞癌 (HCC) 中SKA2的特定作用需要阐明.
研究的目的:
- 综合调查SKA2在肝细胞癌 (HCC) 中的功能作用.
- 探索SKA2表达与HCC患者存活率和临床病理特征的关联.
- 确定潜在的分子机制,包括ceRNA网络,涉及HCC中的SKA2.
主要方法:
- 利用TCGA,TIMER,cBioPortal和其他生物信息学工具进行全面分析.
- 分析了SKA2表达,整体存活率 (OS),以及与瘤阶段和免疫透的相关性.
- 通过使用miRWalk,TargetScanHuman8.0,miRDB,DIANA和Cytoscape,研究了共同表达的基因,微RNA (miRNA) 相互作用和长非编码RNA (lncRNA) 网络.
主要成果:
- 在HCC患者中观察到SKA2表达升高,与更糟糕的OS和晚期瘤相相关.
- SKA2表达与免疫细胞透有显著的关联.
- 确定了参与细胞周期和DNA复制的188个共同表达的基因;阐明了一个涉及SPACA6P-AS/hsa-miR-378a-5p/SKA2,SNHG14/hsa-miR-378a-5p/SKA2和SNHG15/hsa-miR-378a-5p/SKA2的ceRNA网络.
结论:
- SKA2是HCC的预后生物标志物,与瘤阶段和免疫微环境有关.
- SKA2作为竞争的内源RNA (ceRNA) 功能,在HCC瘤发生中发挥着重要作用.
- 这些发现为未来针对HCC中SKA2的治疗策略提供了基础.
更多相关视频
07:02Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
12.6K
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.4K
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K