在膀癌患者中识别功能性cuproptosis相关的长非编码RNA
Yunchao Wang1, Yihan Zhao1, Qing Liu2
1Department of Urology, the First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Translational cancer research
|November 11, 2024
概括
这项研究揭示了与cuproptosis相关的长非编码RNA (lncRNAs) 是膀癌发展的关键. 使用这些lncRNA的新预后特征可以预测患者的生存率并指导治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 膀癌是全世界普遍存在的尿路恶性瘤.
- 质亡,一种新的细胞死亡途径,与癌症的发展有关.
- 了解与cuproptosis相关的基因对于膀癌研究至关重要.
研究的目的:
- 为了研究与cuproptosis相关的基因和膀癌瘤发生之间的相关性.
- 根据与cuproptosis相关的长非编码RNAs (lncRNAs) 开发膀癌的预后特征.
- 评估开发的患者生存签名的预测能力.
主要方法:
- 在癌症基因组图谱 (TCGA) 数据上利用了皮尔森相关性和单变Cox回归.
- 雇佣最小绝对缩小和选择运算符 (LASSO) 考克斯回归来构建预后签名.
- 创建了一个名谱来预测个体患者的生存结果.
主要成果:
- 确定了19个与cuproptosis相关的基因和14个与cuproptosis相关的预后 lncRNAs.
- 开发了一个具有良好的预测精度的七个lncRNA预后风险特征 (1,3年,5年AUC:0.711,0.673,0.684).
- 高风险组的预后较差,与瘤发生,迁移,高化学激素,T细胞抑制和低抗原呈现细胞有关.
结论:
- 与cuproptosis相关的lncRNAs在膀癌瘤发生中发挥着重要作用.
- 这些lncRNAs代表了膀癌的潜在治疗点.
- 基于与cuproptosis相关的lncRNAs的个性化预测签名成功构建.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
03:18Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K