在接受选择性手术的老年人中进行双光谱指数监测的麻醉诱导:在前性,单中心,双盲,随机对照研究中比较齐普罗和普罗波
Haibin Zou1, Fangfang Xi1, Yuanyuan Fu1
1Department of Anesthesiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
与propofol相比,西普罗在老年人中显著降低了麻醉诱导期间的低血压和注射疼痛. 这种新的镇静麻醉剂为老年患者提供了更安全的替代方案.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 西普罗是一种来自中国的新型镇静麻醉剂,具有快速发作/恢复.
- 它在老年人麻醉诱导期间对血压的影响尚未得到充分证实.
研究的目的:
- 为了比较在老年人中,在全身麻醉诱导过程中,西普罗福尔和普罗波福尔诱导的低血压的发生率.
主要方法:
- 这是一项前性,双盲,随机对照试验,涉及117名老年人.
- 患者接受了静脉注射的西普罗 (0.3毫克/千克) 或普罗波 (1.5毫克/千克).
- 主要结局:低血压的发生率 (MAP降低>30%或MAP<65 mmHg).
主要成果:
- 低血压的发生率较低,使用西普罗 (26.3%) 比使用普罗波 (48.3%) (P=0.015).
- 西普罗还显示注射疼痛发生率显著降低 (5.3%对20.7%,P=0.014).
- 这两种药物都在类似的额外剂量要求下实现了100%的诱导成功.
结论:
- 与普罗波相比,西普罗与老年人中低血压和注射疼痛的发生率降低有关.
- 西普罗在老年人中诱导麻醉时表现出有利的安全性,保持稳定的血液循环.
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