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与加拿大太华的慢性运输有关的局部获得的伤寒热病爆发,2018-2022年,加拿大太华
Janice Zhang1,2, Ann Jolly2, Tram Nguyen2
1Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, ON.
概括
一种罕见的慢性沙门氏菌 Typhi 携带者在太华引起了当地伤寒疫情,与一家杂货店有关. 全基因组测序和社交网络分析确定了无症状的食品处理者,导致公共卫生干预.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在加拿大,沙门氏菌 (Salmonella enterica serovar) 感染是罕见的,通常与国际旅行有关.
- 在安大略省太华发生了一起不寻常的疫情,涉及没有旅行史的个人,与杂货店的即食柜台有关.
研究的目的:
- 描述调查和对太华罕见的,长期的伤寒热病爆发的反应.
- 为管理类似的小规模,持久的传染病爆发提供建议.
主要方法:
- 采用多方法方法,包括暴露问卷,便样本测试,食品场所检查和食品/收据收集.
- 采用社交网络分析,空间分析和全基因组测序来识别传输链路.
- 专注于联系人和食品处理人员,包括一个单独的面试官问卷.
主要成果:
- 七例伤寒病例 (2018年10月至2022年5月) 与无症状的慢性沙门氏菌 Typhi 携带者有关.
- 全基因组测序证实所有隔离物与爆发群匹配,病例和携带者位于8公里半径内的地区.
- 传播途径包括食品处理,共享工作空间和社会/家庭网络,源自杂货店连锁店的食品处理人员.
结论:
- 无症状的慢性携带者被确定为来源,并被排除在食品处理之外,直到得到治疗和清除.
- 全基因组测序和社交网络分析的结合在调查这种具有挑战性的,小规模的,长期爆发方面是有效的.
- 公共卫生干预成功地通过识别和隔离无症状携带者来管理疫情.
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