在局部高级口腔癌中新辅助化疗的结果:一项回顾性分析研究
Monesha Baskaran1, S M Azeem Mohiyuddin1, G N Manjunath2
1Otolaryngology - Head and Neck Surgery, Sri Devaraj Urs Medical College, Kolar, IND.
Cureus
|November 11, 2024
概括
新辅助化疗 (NACT) 可以通过减缓瘤的发展,改善局部晚期口腔癌的手术结果. 然而,很大一部分患者对NACT没有反应,这影响了治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 头部和部癌症占印度30%的恶性瘤,口腔状细胞癌是最普遍的.
- 大多数患者 (80%) 患有局部晚期或不可手术的疾病.
- 新辅助化疗 (NACT) 正在探索降低瘤的发展阶段并改善手术切除能力.
研究的目的:
- 评估NACT在局部晚期口腔癌 (T4阶段) 的结果.
- 为了评估疾病的衰退阶段和NACT后接受手术的可能性.
- 为了将NACT响应与组织病理学发现和手术切除充分性相关联.
主要方法:
- 对96名患有局部晚期口腔状细胞癌 (T4a/T4b) 的患者进行了回顾性审查.
- 患者在2018年12月至2022年11月期间接受了两轮NACT.
- 在14个月的随访期间记录了结果,反应率,手术边缘和复发情况.
主要成果:
- 在30.2%的患者中观察到对NACT的部分反应;37.5%的患者有稳定的疾病,30.2%的患者有进展性疾病.
- 对于T4a阶段,33.3%的临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床
- 对于T4b阶段,66.7%的临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床
结论:
- 在局部发达的口腔状细胞癌中,NACT可以促进手术切除.
- 一个显著的百分比的患者 (约30%) 呈现耐药性NACT.
- 瘤对NACT的反应是影响手术结果和复发率的关键因素.
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