在全国范围的队列中,慢性腹腔内血瘤的炎症风险因素
Thorbjørn Søren Rønn Jensen1, Emilia Myrup Thiesson2, Kåre Fugleholm1
1Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, DK-2100, Denmark.
Journal of inflammation research
|November 11, 2024
概括
炎症在慢性下皮质血腫 (CSDH) 中起作用. 这项研究发现了与CSDH相关的炎症因素,即使没有头部创伤,也表明了新的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 炎症研究 炎症研究
- 流行病学 流行病学
背景情况:
- 生物标志物表明,炎症与慢性腹腔内血瘤 (CSDH) 病理生理学有关.
- 目前尚不清楚炎症是否会独立地驱动CSDH,还是由于血液瘤退化的结果.
- 了解这种关系可以确定CSDH患者抗炎治疗的点.
研究的目的:
- 调查促炎和抗炎因素与慢性腹腔内血瘤 (CSDH) 的发展之间的关联.
主要方法:
- 在丹麦 (2007-2018) 进行的一项全国性队列研究包括了50岁以上的个人.
- 根据潜在的风险因素,使用考克斯回归分析来估计首次CSDH手术的危险比率.
- 在分析中,年龄被用作基础时间尺度.
主要成果:
- 在超过230万个人中,头部创伤发生在17%的人中,只有0.18%的人接受了CSDH手术.
- 在没有头部创伤的个体中,酒精成,糖尿病,抗高血压治疗和慢性肝病与CSDH相关 (50-74岁).
- 在75岁以上的患者中,使用葡萄糖皮质类药物降低了CSDH风险,而NSAID和他类药物在年轻年龄组 (50-74岁) 中增加了风险.
结论:
- 头部创伤是CSDH的风险因素,但绝对风险很低,质疑广泛的预防措施.
- 亲和抗炎因素与CSDH显著相关,特别是在没有头部创伤的患者中.
- 这些关联的年龄依赖性表明不同年龄组的病理生理机制不同.
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