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食品加工驱动了Pinellia ternata中的有毒莱克减少和生物活性增强

Xuechun Wang¹, Xiqing Bian², Pingping Dong²

¹State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China.

Current research in food science

|November 11, 2024

概括

食品加工通过减少乳素和增强生物活性来降低Pinellia ternata tuber (PTT) 的毒性. 这项研究确定了抗高血压,提供了对PTT的见解.

科学领域:

食品科学与技术食品科学与技术
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

原始Pinellia ternata tuber (PTT) 是有毒的,因为它含有莱克,限制了它的使用.
食品加工方法可以降低PTT的毒性,但根本的机制尚未完全理解.
在加工的PTT (PPTT) 中识别生物活性对于了解其治疗潜力至关重要.

研究的目的:

阐明在PTT加工过程中降低毒性和增强生物活性的机制.
使用综合分析方法快速发现和描述PPTT中的.
选已识别的的抗高血压活性,并验证它们在商业产品中的存在.

主要方法:

液体染色学-质谱学 (LC-MS) 结合基于特征的分子网络 (FBMN).
De novo序列和蛋白质数据库搜索快速识别.
在子选中,血管素I转化酶 (ACE) 抑制试验,以及用于生物活性评估的分子对接.

主要成果:

加工显著减少了PTT中的有毒学菌素.
在PPTT中鉴定了130种,其中98种是从莱克衍生出来的,许多增加后处理.
五种体表现出ACE抑制活性,其中两种具有131和185微米的IC₅₀值.
为了降低毒性和提高疗效,最佳的处理时间被确定为7-9天.

结论:

食品加工通过降解莱克和产生生物活性来有效降低PTT毒性.
鉴定的具有潜在的抗高血压特性,有助于PPTT的疗效.
应用的方法提供了一种快速有效的方法,用于发现加工食品中的生物活性,适用于阿拉氏植物家族.

关键词:

这是一种抗高血压的药物.生物活性酸是一种生物活性酸.乳清素是一种乳清素.皮内利亚地结 (Pinellia ternata tuber) 是一种植物.处理处理处理

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