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Updated: Jun 7, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

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链接器的特性路线图决定了 PROTACs 的合理设计

Yawen Dong1, Tingting Ma1, Ting Xu1

  • 1School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.

Acta pharmaceutica Sinica. B
|November 11, 2024
PubMed
概括

这项研究分析了蛋白质溶解向金马 (PROTACs),重点关注链接特征如何影响它们在降解致病蛋白质中的有效性. 了解这些因素是设计更有效的PROTAC药物发现工具的关键.

关键词:
生物降解效率的高效率链接器的特征 链接器的特征这就是PROTAC.这是一个PROTAC链接器.理性的设计理性的设计.

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