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怀孕期间施用SpikoGen亚单元疫苗对大鼠胎儿发育的影响

Mehdi Aghsami¹, Hesham Aljoiber¹, Shabnam Mirfendereski²

¹Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.

Clinical and experimental vaccine research

|November 11, 2024

概括

在怀孕期间,SpikoGen亚单元疫苗对大鼠胎儿发育没有任何不良影响. 这项研究发现疫苗接种后对器官生成,骨形成或胎儿形态没有影响.

科学领域:

生殖毒理学生殖毒理学
疫苗安全性研究的研究.
发育生物学是发展生物学.

背景情况:

公众对COVID-19疫苗对生育能力和怀孕影响的兴趣很高.
像SpikoGen这样的子单位疫苗提供了一个有希望的替代方案,但需要在妊娠期间对安全性的评估.
对于评估新型疫苗的潜在发育风险而言,甲状腺生成研究至关重要.

研究的目的:

评估SpikoGen亚单元疫苗对孕鼠胎儿器官生成的影响.
在怀孕的关键时期评估SpikoGen疫苗的安全性.
为疫苗诱导的产生领域提供新数据.

主要方法:

怀孕的老鼠在怀孕前和怀孕期间的各个阶段接受了SpikoGen疫苗 (25微克) 或盐水控制.
胎儿发育在第21天通过剖腹产进行评估,采用形态,骨和组织学分析.
在对照组和接受SpikoGen疫苗的组之间进行了比较分析.

主要成果:

施用SpikoGen疫苗并没有显著改变胎儿体重,大小或形态参数.
没有观察到胎儿的外部形或发育异常.
骨发育,包括不透明度和密度,以及内部器官的形成不受疫苗的影响.

结论:

在小鼠模型中,SpikoGen亚单元疫苗在怀孕期间施用时显示出关于胎儿发育的安全概况.
研究结果表明,在怀孕期间与SpikoGen疫苗接种相关的原性效应不存在.
这项研究支持SpikoGen作为孕妇潜在疫苗选择的安全性,等待进一步的研究.

关键词:

在 COVID-19 疫情中,有机体的产生.怀孕怀孕怀孕怀孕鼠标鼠标鼠标鼠标斯皮科基因 (SpikoGen) 是一种可怕的药物.疫苗疫苗疫苗疫苗

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