治疗前的高系统性免疫炎症指数值预测了绝对化疗放射治疗后胰腺癌的不良结果
Erkan Topkan1, Ahmet Kucuk2, Duriye Ozturk3
1Department of Radiation Oncology, Faculty of Medicine, Baskent University, Adana, Turkey.
Clinical Medicine Insights. Oncology
|November 11, 2024
概括
系统性免疫炎症指数 (SII) 可以预测接受化疗放射治疗的局部晚期胰腺癌患者的结果. 较高的治疗前SII水平与明显较差的整体存活率和无进展存活率有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 系统性免疫炎症指数 (SII) 是各种癌症的预后标志物.
- 它的预测价值在局部晚期胰腺管腺癌 (LA-PDAC) 治疗的确定的化疗放射治疗是不确定的.
研究的目的:
- 调查在接受同时化学放射治疗 (C-CRT) 的无法切除的LA-PDAC患者中预后SII的预后意义.
主要方法:
- 对接受C-CRT的163名LA-PDAC患者进行了回顾性分析.
- 接收器运行特征 (ROC) 曲线分析,以确定最佳的SII切断点,以实现生存分层.
- 评估总生存 (OS) 和无进展生存 (PFS) 作为初级和二级终点.
主要成果:
- 在538名分层成两组的患者中,预治疗SII的切断值.
- 与SII≥538患者相比,SII≥538患者的中位寿命显著缩短 (13.0个月与25.4个月) 和PFS (7.0个月与15.2个月) 相比,SII≥538患者的中位寿命显著缩短 (13.0个月与25.4个月).
- 多变量分析确定高SII (≥538),ECOG性能状态为2,N1-2淋巴结参与,CA 19-9 (>90U/mL) 升高作为劣质生存的独立预测因素.
结论:
- 治疗前的SII是C-CRT治疗不可切除的LA-PDAC患者的生存的重要独立预后因素.
- 预治疗SII≥538与较差的OS和PFS结局有关.
更多相关视频
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
1.2K
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
454
相关概念视频
01:24Chronic Pancreatitis I: Introduction
72
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
72
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70