临床和非临床语音听者的不匹配负面反应的不同模式挑战了精神病的预测编码账户
Molly A Erickson1, Sonia Bansal2, Charlotte Li1
1Department of Psychiatry & Behavioral Neuroscience, University of Chicago Medical Center, Chicago, Illinois.
在精神分裂症中减少的不匹配负面性 (MMN) 与幻觉等积极症状无关. 这项研究发现MMN不是这些特定精神病体验的可靠指标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 在精神分裂症患者 (PSZ) 中,减少不匹配负面性 (MMN) 往往与破坏的预测错误信号与潜在的积极症状有关.
- 然而,MMN和积极症状之间的相关性是不一致的,挑战了这种解释.
- 这项研究调查了减少的MMN是否与幻觉和妄想有关,而不是与精神分裂症有关.
研究的目的:
- 测试减少的MMN是否与幻觉和妄想有具体联系.
- 检查MMN与积极症状的关联是否通过更高层次的预测处理得到加强.
- 区分MMN在精神分裂症中的作用与它在非临床声音听者中的存在.
主要方法:
- 56名PSZ,34名非临床语音听者和48名健康对照受试者 (HCs) 参与了这项研究.
- 使用了两个MMN范式:一个是持续时间偏差,另一个是更高层次的模式违规偏差.
- 测量了重复的积极性,以评估听觉记忆的痕迹形成.
主要成果:
- 与HC相比,PSZ显示了减少持续时间的MMN和趋势水平的减少模式违规的MMN.
- 非临床语音听者对两种范式来说,MMN的幅度与HC的幅度统计上相似.
- PSZ表现出减少的重复阳性倾斜率,而非临床语音听者与HCs没有区别.
结论:
- 作为预测错误信号的MMN似乎与幻觉和妄想的表现没有直接关系.
- 这些发现表明,MMN的减少并不特定于精神分裂症的积极症状.
- 非临床患者的听觉幻觉与MMN变化无关.
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