克罗恩病管理:为英国的临床实践翻译STRIDE-II
Karen Kemp1, Mark A Samaan2, Ajay M Verma3
1Department of Gastroenterology, Manchester Clinical Academic Centre, Manchester Royal Infirmary, University of Manchester, Oxford Road, Manchester M13 9WL, UK.
Therapeutic advances in gastroenterology
|November 11, 2024
概括
以STRIDE-II为指导的治疗到目标 (T2T) 方法为克罗恩病提供了更好的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床实践指南 临床实践指南
背景情况:
- 克罗恩病 (CD) 管理传统上使用阶段性疗法,但临床缓解与疾病活动的相关性很差.
- 仅实现临床缓解或内镜治疗可能无法预防CD患者的炎症并发症.
- 个性化"治疗到目标" (T2T) 策略显示出增强CD内镜缓解和症状缓解的潜力.
研究的目的:
- 总结关于克罗恩病 (CD) 管理的STRIDE-II指导方针.
- 为医疗保健专业人员提供有关在英国临床实践中应用STRIDE-II原则的指导.
- 为不响应的CD患者提供管理建议,并建议使用内镜结果评分系统.
主要方法:
- 对STRIDE-II指南的审查和总结.
- 为英国临床医生制定实际建议.
- 包括对初级和二级不响应者的管理策略.
- 关于使用内镜结果评分系统的指导.
主要成果:
- STRIDE-II指南为IBD的T2T治疗提供了基于证据的,个性化的目标.
- 目标包括长期目标 (生活质量,残疾,内镜治疗) 和短期目标 (症状,生物标志物).
- 这些指导方针有助于对治疗策略进行风险益处评估.
结论:
- STRIDE-II指导方针为CD中的个性化T2T管理提供了一个框架.
- 应用这些指导方针可以改善英国的患者结果和临床实践.
- 专注于超越简单缓解的具体目标对于有效的CD管理至关重要.
相关概念视频
Inflammatory Bowel Disease IV: Pharmacological Management
114
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
114
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
96
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
96
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
142
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
142
Inflammatory Bowel Disease II: Crohn's Disease
186
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
186
Inflammatory Bowel Disease V: Surgical Management
122
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
122
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
319
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
319


