糖尿病外围神经病变和糖血症风险指数在2型糖尿病:一个横截面研究
Yuchen Tang1, PingPing Zhang2, Li Li1
1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|November 11, 2024
概括
通过持续血糖监测 (CGM) 测量的高血糖风险指数 (GRI) 水平与2型糖尿病患者糖尿病外围神经病变 (DPN) 的风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病外围神经病变 (DPN) 是2型糖尿病 (T2DM) 的常见并发症.
- DPN与慢性高血糖和血糖变异性有关.
- 持续血糖监测 (CGM) 提供了对血糖模式的详细见解.
研究的目的:
- 调查T2DM患者的血糖风险指数 (GRI) 和DPN之间的关联.
- 使用CGM数据计算GRI并评估其与DPN的相关性.
- 为了确定GRI升高是否预测患DPN的风险更高.
主要方法:
- 862名患有T2DM的成年人被录取到第三级护理糖尿病中心.
- 收集了14天的CGM数据来计算血糖风险指数 (GRI).
- 多变量逻辑回归分析了DPN的几率比 (OR) 与GRI四分位数的增加,以多种临床因素进行调整.
主要成果:
- 在上升的GRI四分位数中,DPN患病率增加 (41.6%至59.5%,P<0.001).
- 与最低四分位数相比,最高GRI四分位数显示DPN风险增加了63% (OR为1.631).
- 这种关联在调整年龄,BMI,糖尿病持续时间和其他代谢参数后仍然显著.
结论:
- 来自CGM的高血糖风险指数 (GRI) 水平显著与T2DM患者糖尿病外围神经病变 (DPN) 的可能性增加有关.
- 在2型糖尿病患者中,GRI作为DPN风险评估的潜在指标.
- 进一步的研究可能会探索针对血糖变化的干预措施,以减轻DPN进展.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Symptoms, Diagnosis, and Complications
508
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
508
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Pathophysiology of Diabetes
872
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
872
Diabetes: Management and Pharmacotherapy
236
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
236


