针对生殖线DDX41突变的急性髓性白血病进行全源性造血干细胞移植
Shuro Yoshida1, Yuichiro Semba2,3, Shuichiro Takashima1
1Department of Hematology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Case reports in hematology
|November 11, 2024
概括
生殖线DEAD-box螺旋酶41基因 (DDX41) 突变被新归类为髓状瘤. 建议对具有DDX41突变的急性髓性白血病 (AML) 进行全源造血干细胞移植 (HSCT),以改善结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 2016年世界卫生组织的分类新包括了与髓状瘤相关的生殖系DEAD-box化酶41基因 (DDX41) 突变.
- 带有生殖系DDX41突变的急性髓性白血病 (AML) 的临床轨迹仍然不完全理解,早期呈现缓慢进展和高缓解率,但后来复发率增加和预后较差.
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