临床药剂师干预营养和药物相关问题的临床药剂师在关键病患者的功能障碍:一个非随机对照研究
Betül Özgan1, Yunus Emre Ayhan2, Sule Apikoglu1
1Department of Clinical Pharmacy, Marmara University Faculty of Pharmacy, Istanbul, Türkiye.
Frontiers in medicine
|November 11, 2024
概括
临床药剂师显著减少了与药物相关的问题 (DRP) 和与营养相关的问题 (NRP) 在关键病情ICU患者的功能障碍. 这种干预措施通过有效地解决药物和营养需求,改善了患者的治疗结果.
科学领域:
- 关键护理医学 关键护理医学
- 临床药房 临床药房 临床药房
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 在重症监护室 (ICU) 的重症患者面临着危及生命的药物相关问题 (DRPs) 和营养不良的高风险.
- 临床药剂师 (CP) 对于管理这些问题和改善患者的治疗结果至关重要.
研究的目的:
- 评估临床药房服务对检测,预防和解决营养相关问题 (NRPs) 和DRPs在患有功能障碍的重症监护病人的影响.
- 评估CP干预措施在改善营养状况和药物安全方面的有效性.
主要方法:
- 一个为期9个月的,前性,非随机的,在ICU环境下进行的受控研究.
- 临床医生为NRP和DRP提供了建议,这些建议使用专家开发的肠道营养共识协议和PCNE与药物相关问题的分类v9.1.1.进行评估.
- 干预期 (IP) 与观察期 (OP) 数据相比.
主要成果:
- 总共有504名DRP被确定 (每名患者8.4). 在IP期间,DRPs下降了50% (p < 0.001).
- 最常见的DRP原因是:"药物剂量太低" (22.2%),"药物相互作用" (17%) 和"药物剂量太高" (16.4%).
- 在97.9%的案例中,CP的建议被接受. 目标卡路里和蛋白质补充剂在IP期间在更多患者中实现 (p <0.05).
结论:
- 患有功能障碍的ICU患者表现出DRP和营养不良风险的高发病率.
- 临床药房服务对于减少这种患者群体的DRP和NRP至关重要.
- 中医和医疗保健专业人员之间的合作显著改善了患者的护理和结果.
相关概念视频
01:11Renal Failure: Dose Adjustments
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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01:17Factors Affecting Renal Clearance: Renal Impairment
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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01:09Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions
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Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
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102
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
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Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
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CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
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01:22Heart Failure Drugs: Diuretics
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01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
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