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通过结合体仿真在地球早期的核糖核酸识别动机的起源

Deepto Mozumdar¹, Raktim N Roy²

¹Department of Immunology & Microbiology, University of California San Francisco, San Francisco, CA, USA.

|November 11, 2024

概括

在蛋白质进化以模仿这些RNA结合功能之前,早期的RNA分子可能已经识别了小分子和矿物质. 这项研究探讨了RNA识别动机的演变.

科学领域:

生命的起源研究生命的起源研究
分子进化分子进化
生物化学生物化学

背景情况:

RNA世界假说假定RNA是DNA和蛋白质的前体,需要早期的RNA分子拥有自我复制和催化能力.
可靠的RNA-RNA识别动机的演化对于理解从原始RNA世界向现代DNA-蛋白质世界过渡至关重要.
这些早期RNA识别动机的直接证据由于地质时间尺度上的降解而丢失.

研究的目的:

研究生命早期RNA识别动机的性质和演变.
探索RNA分子最初如何与小分子,矿物质和金属离子相互作用.
了解从基于RNA的识别过渡到基于蛋白质的RNA结合域.

主要方法:

审查现存生物体中保存的序列和结构图案.
利用定向进化实验来产生具有特定催化能力的RNA.
检查关于矿物和金属离子在RNA识别和催化中的作用的假设.

主要成果:

RNA可能与小分子和无机共因子 (矿物质,金属离子) 相互作用,用于结构识别和催化.
在RNA-RNA相互作用中RNA-蛋白质模拟的实例表明蛋白质参与的途径.
提出了一个假设,最初对小分子和矿物质的RNA识别后来被蛋白质模仿.

结论:

RNA识别小分子和无机共因子的能力是早期生物过程的基础.
蛋白质RNA结合域可能是通过模仿这些祖先RNA识别机制而演变的.
了解这些早期识别事件,可以了解复杂的生物系统从更简单的前体的出现.

关键词:

在RNA世界.RRM RRM 是一个很好的方法.核酸核酸的识别方法它们是Aptamers.肋骨开关肋骨开关肋骨开关

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