mOTU的在线数据库为微生物群落的分类学概况提供了可访问的基因组背景
Marija Dmitrijeva1, Hans-Joachim Ruscheweyh1, Lilith Feer1
1Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, 8093 Zürich, Switzerland.
Nucleic acids research
|November 11, 2024
概括
mOTU的数据库提供了数以百万计的微生物基因组,有助于微生物群落的分类学概况. 本资源通过将基因组数据与配置文件的种群联系起来,增强对微生物多样性的理解.
科学领域:
- 微生物学 微生物学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 分类学概况对于理解微生物群落至关重要.
- 获取配置文件的种群的基因组背景是具有挑战性的.
- 微生物基因组的多样性仍然不足.
研究的目的:
- 介绍微生物基因组学的mOTUs数据库 (mOTUs-db).
- 为分类学分析提供一个全面的资源.
- 促进对微生物基因组多样性的探索.
主要方法:
- 编译了283万个元基因组组装基因组 (MAG).
- 整合了919090个单细胞和分离基因组.
- 使用跨样本的支架丰度相关性重新构建的MAG de novo.
主要成果:
- mOTUs-db包含283万个MAG和超过90万个其他基因组.
- 数据库涵盖了124,295个物种级分类学单位.
- 与GTDB相比,超过50%的物种级组是独一无二的.
结论:
- mOTUs-db 是一个主要的 prokaryotic 基因组资源.
- 该数据库通过提供基因组背景来增强分类学概况.
- 交互式查询可以广泛访问微生物基因组数据.
相关概念视频
Applications of Molecular Taxonomy
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
Microbial Classification System
1
Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
1
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Genomics
36.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.0K
MALDI-TOF Mass Spectrometry
4.7K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.7K


