dbPTM 2025更新:全面整合PTM和蛋白质组数据,为癌症研究提供先进的见解
Chia-Ru Chung1, Yun Tang2, Yen-Peng Chiu3
1Department of Computer Science and Information Engineering, National Central University, No. 300, Zhongda Rd., Zhongli Dist., Taoyuan City 320317, Taiwan.
Nucleic acids research
|November 11, 2024
概括
dbPTM 2025数据库现在包括超过279万个翻译后修改 (PTM) 站点,重点是癌症蛋白质组数据. 此资源有助于研究人员探索PTM及其在癌症中的作用.
科学领域:
- 生物化学 生化学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 翻译后修改 (PTM) 对蛋白质的功能,稳定性,活性和信号传递至关重要.
- dbPTM数据库是PTM信息的重要资源.
研究的目的:
- 介绍dbPTM 2025数据库更新的重大扩展和新功能.
- 突出癌症特异性蛋白质组数据和监管网络的整合.
- 提高dbPTM对癌症研究和与疾病相关的PTM研究的实用性.
主要方法:
- 扩大dbPTM数据库,包括超过279万个PTM站点 (2243万个实验验证).
- 整合了来自13种癌症类型的蛋白质组数据,重点关注蛋白质组和激酶活性.
- 纳入酶基质酸化和E3酶基质相互作用,以映射PTM监管网络.
- 开发高级搜索功能,交互式可视化工具和简化数据下载.
主要成果:
- dbPTM 2025现在包含超过279万个PTM站点,其中2243万个经过实验验证.
- 该数据库整合了广泛的癌症蛋白质组数据,使得瘤中的个性化酸化模式分析成为可能.
- 新功能促进了有效的数据查询,分析和探索PTM监管网络.
- 提供了增强的功能注释,监管网络和疾病关联.
结论:
- dbPTM 2025是研究PTM的全面和用户友好的资源.
- 更新的数据库通过提供有关PTM及其监管网络的详细见解,显著推动了癌症研究.
- dbPTM 2025促进了与疾病相关的PTM和个性化癌症治疗的调查.
更多相关视频
10:37Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
11.9K
09:52A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
Published on: January 10, 2025
498
相关概念视频
01:33Proteomics
7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K
01:33Peptide Identification Using Tandem Mass Spectrometry
6.4K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.4K