iDog:一个多主题的资源,用于 canids 研究研究
Yanhu Liu1, Yibo Wang2,3,4, Jiani Sun2,3,4,5
1Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650091, China.
Nucleic acids research
|November 11, 2024
概括
更新后的iDog 2.0平台显著扩展了犬类基因组和多组数据,为研究养犬和野生犬类动物的研究人员提供了增强的资源. 这种全面的数据库现在包括数百万个遗传变异,基因表达数据和表型信息,以推进犬类研究.
科学领域:
- 基因组学和生物信息学
- 进行比较基因组学.
- 狗研究研究 狗研究
背景情况:
- 该iDog数据库是狗研究的重要公共资源.
- 之前的版本为养狗 (Canis lupus familiaris) 和野生犬类提供了基础的多组数据.
- 确定了扩展基因组,转录基因组和表型数据整合的需要.
研究的目的:
- 介绍iDog 2.0平台的显著增强和扩展功能.
- 为全球犬科研究社区提供综合,全面的资源.
- 促进在狗遗传学,基因组学和疾病研究中以数据为导向的发现.
主要方法:
- 整合基因组样本增加15倍,包括现代和古代Canis DNA.
- 包括广泛的单核酸多态 (SNP) 和插入/删除 (InDel) 变体数据.
- 纳入基因表达 (转录组,单细胞),表观基因组 (DNA甲基化,染色质可访问性) 和表型数据.
主要成果:
- 现在iDog 2.0包含了来自1929年现代和111个古老的Canis样本的数据,其中包括数百万个SNP和InDels.
- 该平台集成了特定品种的SNP,与疾病相关的变异,基因表达数据集和单细胞转录组学.
- 包括表观基因组数据,关于狗疾病的广泛表型信息,基因型对表型对和标准化本体学.
结论:
- 增强的iDog 2.0代表了对犬类研究的大幅扩展和宝贵资源.
- 该平台的综合多学科数据和分析工具支持各种研究途径.
- iDog 2.0 准备加速犬类遗传学,繁殖和疾病理解方面的发现.
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