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相关概念视频

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Updated: Jun 7, 2025

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research
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iDog:一个多主题的资源,用于 canids 研究研究.

Yanhu Liu1, Yibo Wang2,3,4, Jiani Sun2,3,4,5

  • 1Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650091, China.

Nucleic acids research
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概括
此摘要是机器生成的。

更新后的iDog 2.0平台显著扩展了犬类基因组和多组数据,为研究养犬和野生犬类动物的研究人员提供了增强的资源. 这种全面的数据库现在包括数百万个遗传变异,基因表达数据和表型信息,以推进犬类研究.

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科学领域:

  • 基因组学和生物信息学
  • 进行比较基因组学.
  • 狗研究研究 狗研究

背景情况:

  • 该iDog数据库是狗研究的重要公共资源.
  • 之前的版本为养狗 (Canis lupus familiaris) 和野生犬类提供了基础的多组数据.
  • 确定了扩展基因组,转录基因组和表型数据整合的需要.

研究的目的:

  • 介绍iDog 2.0平台的显著增强和扩展功能.
  • 为全球犬科研究社区提供综合,全面的资源.
  • 促进在狗遗传学,基因组学和疾病研究中以数据为导向的发现.

主要方法:

  • 整合基因组样本增加15倍,包括现代和古代Canis DNA.
  • 包括广泛的单核酸多态 (SNP) 和插入/删除 (InDel) 变体数据.
  • 纳入基因表达 (转录组,单细胞),表观基因组 (DNA甲基化,染色质可访问性) 和表型数据.

主要成果:

  • 现在iDog 2.0包含了来自1929年现代和111个古老的Canis样本的数据,其中包括数百万个SNP和InDels.
  • 该平台集成了特定品种的SNP,与疾病相关的变异,基因表达数据集和单细胞转录组学.
  • 包括表观基因组数据,关于狗疾病的广泛表型信息,基因型对表型对和标准化本体学.

结论:

  • 增强的iDog 2.0代表了对犬类研究的大幅扩展和宝贵资源.
  • 该平台的综合多学科数据和分析工具支持各种研究途径.
  • iDog 2.0 准备加速犬类遗传学,繁殖和疾病理解方面的发现.