2024年CORUM:蛋白质复合物成为药物点
Ralph Steinkamp1, George Tsitsiridis1, Barbara Brauner1
1Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, Neuherberg D-85764, Germany.
Nucleic acids research
|November 11, 2024
概括
现在CORUM 5.0数据库包括药物对哺乳动物蛋白质复合体的影响,扩大其用于药物发现和网络医学研究的实用性. 这一更新将725种药物标与1975年文献记录的药物蛋白复杂相互作用实例联系起来.
科学领域:
- 生物化学和分子生物学
- 药理学 药理学是指药理学的学科.
- 生物信息学是一种生物信息学.
背景情况:
- 哺乳动物蛋白质复合体在细胞过程中起着至关重要的作用.
- 了解药物与蛋白质复合物的相互作用对于药物疗效至关重要.
- 科鲁姆数据库提供有关蛋白质复合体的精选信息.
研究的目的:
- 更新和扩展CORUM数据库,提供有关哺乳动物蛋白质复合体的最新信息.
- 系统地调查和整合药物对蛋白质复合体影响的数据.
- 增强CORUM在药理学研究和网络医学方面的实用性.
主要方法:
- 用于CORUM 5.0.0 的蛋白质复合体数据的手动化.
- 整合来自DrugCentral的药物目标信息.
- 文献挖掘以确定药物-蛋白质复杂相互作用.
主要成果:
- CORUM 5.0 包含 7193 个手工策划的哺乳动物蛋白质复合体,这是目前可用的最大数据集.
- 1975从文献中确定了对蛋白质复合体形成/功能药物影响的实例.
- 该数据库现在将725种蛋白质药物标与已批准的药物和已知的作用机制联系起来.
结论:
- CORUM 5.0是一个重要的升级,提供了关于哺乳动物蛋白质复合物的最全面的资源.
- 包括药物-蛋白质复杂相互作用在内,提高了对药物机制和疗效的理解.
- 这种扩展的资源将有助于推进网络医学和药理学研究.
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