幸存者促进干细胞对皮肤癌启动的能力
Sara Canato1, Rahul Sarate2, Sofia Carvalho-Marques1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Cancer discovery
|November 11, 2024
概括
幸存者蛋白对于由干细胞 (SCs) 启动皮肤癌至关重要. 它使SC细胞能够存活和自我更新,防止分化和亡,与原始细胞 (Ps) 不同.
科学领域:
- 在瘤学瘤学.
- 干细胞生物学 干细胞生物学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤癌是由正常细胞过程的失调引起的.
- 干细胞 (SCs) 和原生细胞 (Ps) 在组织恒温和疾病中发挥着不同的作用.
- 了解驱动皮肤癌发病的分子机制对于开发向疗法至关重要.
研究的目的:
- 确定关键调节者,区分皮肤干细胞 (SCs) 与原生细胞 (Ps) 的致癌潜力.
- 阐明Survivin在瘤基因向性SCs的生存,自我更新和分化中的作用.
- 为了确定为什么SCs,但不是Ps,可以启动皮肤癌.
主要方法:
- 在皮肤干细胞 (SCs) 和原生细胞 (Ps) 中Survivin表达的分析.
- 研究Survivin调节对SC生存,自我更新,分化和亡的影响.
- 利用瘤基因诱导的皮肤癌模型来评估Survivin在瘤开始中的作用.
主要成果:
- 幸存者被确定为皮肤癌发病的关键调节者.
- 在瘤基因向性SC中生存表达对于它们的生存和自我更新至关重要.
- 幸存者预防SC的分化和亡,使他们能够启动皮肤癌,这是Ps没有观察到的功能.
结论:
- 幸存者在赋予皮肤干细胞 (SCs) 致癌能力方面发挥着关键作用.
- 向生存可能提供一种策略,通过防止SC存活和促进它们的分化或亡来抑制皮肤癌的发病.
- 在SCs和Ps中Survivin的差异表达和功能解释了它们在皮肤瘤发生中的不同作用.
相关概念视频
01:12Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
01:26Stem Cell Niche
5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:30Skin Cancer
3.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.8K
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.4K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.4K