基于一种新的方法,预测血液压力对脏化的反应
Venera Bytyqi1, Dennis Kannenkeril1, Kristina Striepe1
1Department of Nephrology and Hypertension.
对脏缩 (RDN) 反应者的新定义识别了显著降低血压 (BP) 的患者. 成功RDN的关键预测因素包括更低的BMI,更少的药物和更高的心率.
科学领域:
- 心血管医学 心血管医学
- 干预性心脏病学 干预性心脏病学
- 高血压管理 高血压管理
背景情况:
- 鉴定血压 (BP) 对脏缩 (RDN) 反应的预测因素对于患者的选择至关重要.
- 怀尔德原则表明,基线血压影响抗高血压干预后的血压变化.
- 提出了BP响应者的新定义,考虑了基线BP和RDN特异性影响.
研究的目的:
- 提出和验证一种新的血压 (BP) 的定义,即对脏缩 (RDN) 的反应者.
- 为了确定BP对RDN反应的预测因素.
- 为了区分RDN特定的BP变化与基线BP相关的影响.
主要方法:
- 148名患有失控高血压的患者接受了RDN.
- 24小时的门诊血压 (ABP) 在基线和手术后6个月被测量.
- 通过从观察到的SBP降低中减去预测的SBP降低来计算RDN特异效应.
主要成果:
- 在响应者中,RDN 特定的 (剩余) 24 小时 ABP 显著下降 (-14.9/-8.2 mmHg).
- 受访者表现出较少的抗高血压药物,更高的基线和24小时心率 (HR),更低的BMI,以及没有2型糖尿病 (T2D).
- 中性响应者显示血压变化最小 (1.0/0.2 mmHg),而非响应者则呈现最小的残留下降 (-14.2/-8.3 mmHg).
结论:
- 拟议的定义有效地将基线BP相关的变化与RDN特定影响分开.
- 对RDN血压反应的积极预测因素包括低BMI,较少的抗高血压药物,高基线办公室HR,高24小时门诊HR和T2D的缺失.
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