在新鲜体外受精 (IVF) 周期的卵巢刺激期间,乳酸菌在不同年龄组中的丰富程度是否有差异?
Haris Zukić1, Devleta Balić2, Džanan Osmanović2
1Clinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, Bosnia and Herzegovina.
概括
老龄化增加了新鲜的试管婴儿周期期间子宫内膜中的乳酸菌,影响了生育治疗. 身体质量指数 (BMI) 与乳酸菌或阴道菌水平没有相关性.
科学领域:
- 生殖医学 生殖医学
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 子宫内膜微生物组在体外受精 (IVF) 程序的成功中起着至关重要的作用.
- 了解影响子宫内膜微生物群的因素对于改善试管婴儿结果至关重要.
研究的目的:
- 研究年龄和身体质量指数 (BMI) 对乳杆菌种类丰富性的影响. (LS) 和宫内膜中的阴道菌 (GV).
- 确定子宫内膜微生物组成与新鲜胚胎移植 (ET) 在IVF中的成功之间的关系.
主要方法:
- 预期单中心研究,涉及接受新鲜胚胎移植 (ET) 的患者.
- 使用胚胎移植导管尖端收集的子宫内膜样本.
- 使用实时聚合酶链反应 (RT-PCR) 进行LS和GV的定量分析.
- 患者分为年龄组 (<35岁和≥35岁) 和BMI组 (正常:18.5-24.9 kg/m2,增加:≥25 kg/m2).
主要成果:
- 乳杆菌菌种类. 乳杆菌种类. (LS) 在96.4%的患者中被检测到.
- 老年患者 (≥35岁) 与年轻患者相比,显示出更高的LS中位数 (较低的Cq RT-PCR值).
- 在36.8%的患者中检测到Gardnerella vaginalis (GV),年龄组之间的数量没有显著差异.
- 身体质量指数 (BMI) 与子宫内膜腔中的LS量没有相关性.
结论:
- 衰老显著影响子宫内膜微生物组的组成.
- 增加的年龄与更高的Lactobacillus spp.丰度有关. 在子宫内膜中.
- 身体质量指数 (BMI) 在新鲜的试管婴儿周期中似乎没有影响子宫内膜的乳酸菌或菌水平.
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