智能药物输送的双响应纳米粒子:一个基于NIR光敏感和氧反应的PEG-PCL系统
Nancy Ferrentino1, Taha Behroozi Kohlan2, Shokoufeh Mehrtashfar2,3
1Dipartimento di Scienze e Tecnologie, Università del Sannio, via de Sanctis snc, 82100 Benevento, Italy.
Biomacromolecules
|November 11, 2024
概括
本研究介绍了一种使用聚合物纳米粒子的双响应药物递送系统. 这些纳米粒子在接触到特定的光或生物刺激时释放药物,为向治疗提供了一种智能方法.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
背景情况:
- 响应刺激的聚合物纳米粒子 (NP) 是先进的药物递送系统 (DDS).
- 它们可以控制由外部或内部刺激触发的药物释放.
- 开发双响应系统可以提高治疗精度.
研究的目的:
- 为了合成和表征一种用于药物输送的新型双响应的triblock共聚合物.
- 为了研究尼罗河红色 (NR) 载荷NP的刺激触发释放.
- 评估开发的NP的生物相容性和细胞吸收.
主要方法:
- 合成聚乙烯基醇和聚乙烯基醇 (PCL-SS-PEG-SS-PCL) 的共聚物.
- 使用NMR,SEC和FTIR进行表征.
- 通过DLS和FESEM准备和分析尼罗河红色载荷NP.
- 使用光光谱学在UV/NIR光和GSH刺激下监测药物释放.
- 通过光显微镜评估AlamarBlue测定和细胞吸收的细胞活力.
主要成果:
- 双反应性共聚物的成功合成.
- 尼罗河红色载荷NP在UV/NIR光和GSH暴露后显示有控制的释放.
- 同时的刺激导致药物释放加速.
- 负载NR的NP表现出良好的细胞活力和有效的细胞吸收在人类皮肤纤维细胞.
结论:
- 合成的PCL-SS-PEG-SS-PCL共聚合物形成了有效的双响应NP用于药物输送.
- 该系统显示了有针对性和受控释放应用的潜力.
- 这些NP是生物相容的,并且很容易被细胞内化,这表明智能治疗策略的前景.
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