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Updated: Jun 7, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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沙宾内合成酶的结构和功能,一种产生高度紧张的单烯循环酶 [3.1.0] 循环产物

Matthew N Gaynes1, Kristin R Osika1, David W Christianson1

  • 1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

Biochemistry
|November 11, 2024
PubMed
概括

研究人员阐明了sabinene合成酶的结构和生化基础,揭示了突变如何可以重新编程烯循环,以产生不同的双循环产物,如α-pinene.

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The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
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In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
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