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通过化物抽象氧化催化:使用偏磁放松增强NMR的方法开发和机制研究

  • 0Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Journal of the American Chemical Society +

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2024年十一月11日

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Syn Dihydroxylation Mechanism
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Reduction of Alkynes to <em data-lazy-src=

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Alkynes can be reduced to trans-alkenes using sodium or lithium in liquid ammonia. The reaction, known as dissolving metal reduction, proceeds with an anti addition of hydrogen across the carbon–carbon triple bond to form the trans product. Since ammonia exists as a gas (bp = −33°C) at room temperature, the reaction is carried out at low temperatures using a mixture of dry ice (sublimes at −78°C) and acetone. 
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