在四足动物的脊椎配方中,有同源和非同源的模式
Rory T Cerbus1,2, Ichiro Hiratani1, Kyogo Kawaguchi2,3,4,5
1Nonequilibrium Physics of Living Matter RIKEN Hakubi Research Team, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
概括
脊椎公式揭示了脊椎动物进化中的同源性转变. 通过分析四足动物的数据,我们发现脊椎数量的反向关系,这表明在受霍克斯基因影响的身体规划发展中存在进化性权衡.
科学领域:
- 进化发育生物学 进化发育生物学
- 进行比较的基因组学.
- 脊椎动物的古生物学
背景情况:
- 脊椎配方将脊椎动物的发育和原始发育联系在一起.
- 保存的霍克斯基因集群是理解脊椎模式的关键.
- 模型生物中的同源转变表明霍克斯基因对脊椎身份的影响.
研究的目的:
- 在四足动物的脊椎公式中研究全身轴上的同源关系.
- 测试假设脊椎数量是由于同源性变化而相反相关的.
- 在各种脊椎动物中探索霍克斯基因集群与脊椎模式的相关性.
主要方法:
- 编制了一个完整的四足动物脊椎公式的综合数据集.
- 系统地分析了脊椎数组的组合,以寻找同源模式.
- 在HoxB基因集群中,与基因间距离相关的脊椎数量.
主要成果:
- 在脊椎数目中确定了哺乳动物的同源模式.
- 发现了新的远端脊椎平衡,这些平衡不是通过简单的霍克斯脊椎关系来预测的,包括热足动物到鸟类的过渡.
- 发现了脊椎数量和HoxB基因间距离之间的相关性,挑战了线性Hox表达模型.
结论:
- 脊椎配方的定量分析修订了对霍克斯介导的脊椎动物体型多样性的预期.
- 在脊椎动物进化过程中,同源性变化可能比以前认为的发挥更广泛的作用.
- 霍克斯基因组织和脊椎模式之间的关系比简单的直线模型更复杂.
相关概念视频
General Structure of a Vertebra
2.6K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
2.6K
Vertebral Column: Regions and Curvature
3.5K
The vertebral column or spine is a flexible column that supports the head, neck, and body and allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
3.5K
Gastrulation
56.7K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
56.7K
Articulations of the Vertebral Column
1.8K
In addition to being held together by the intervertebral discs, adjacent vertebrae also articulate with each other at synovial joints formed between the superior and inferior articular processes called zygapophysial joints (facet joints). These are plane joints that provide for only limited motions between the vertebrae. The orientation of the articular processes at these joints varies in different regions of the vertebral column and serves to determine the types of motions available in each...
1.8K
Overview of the Axial Skeleton
5.1K
The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...
The axial skeleton of the...
5.1K
Neurulation
41.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.7K


