接受全新辅助疗法的直肠癌早期,诱导后恢复是否与最终的治疗反应有关?
William C Chapman1, Emre Gorgun1, Sumeyye Yilmaz1
1Department of Colorectal Surgery, Digestive Disease and Surgery Institute, The Cleveland Clinic, Cleveland, Ohio.
Diseases of the colon and rectum
|November 11, 2024
概括
在直肠癌诱导疗法后的早期重置预测了最终的治疗反应. 完全或最小响应者显示出更好的结果,但部分响应的意义仍然不清楚.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 总的新辅助疗法 (TNT) 用于直肠癌.
- 在TNT后的早期重置和最终瘤反应之间的关联还不清楚.
- 临时重新分期可能会影响直肠癌管理中的治疗决策.
研究的目的:
- 为了确定使用内镜和MRI的诱导后重置是否与接受TNT的直肠癌患者的最终瘤反应相关.
主要方法:
- 追溯的队列研究.
- 包括活检证明的直肠癌患者,接受TNT治疗和临时重置阶段.
- 评估了诱导后重新分期反应和最终治疗反应之间的关联.
主要成果:
- 分析了107名患者.
- 诱导后MRI等级1-2或完整的内镜反应预测最终完整反应的可能性更高 (OR 5.4,p<0.01和OR 3.7,p=0.03).
- 诱导后的部分或最小反应与最终不完全反应的几率显著增加 (OR 4.1,p<0.01和OR 12.0,p<0.01).
结论:
- 瘤对诱导疗法的反应与TNT中完全或最小响应者的最终治疗反应有关.
- 部分临时反应的临床意义需要进一步调查.
- 局限性包括回顾性设计,有限的样本大小,以及缺乏部分内镜反应的详细分类.
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