剩余的Mycobacterium bovis感染对于根除牛结核病所带来的问题
J Wiseman1, J P Cassidy2, E Gormley2
1Veterinary Sciences Centre, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland; Department of Agriculture, Food and the Marine, Central Veterinary Research Laboratory - Backweston Campus, Young's Cross, Celbridge, Co. Kildare, Ireland.
Veterinary journal (London, England : 1997)
|November 11, 2024
概括
牛中未被诊断的Mycobacterium bovis感染,称为残留或潜伏,阻碍了牛结核 (bTB) 根除工作. 改进的诊断对于检测这些持续性感染和防止群体崩至关重要.
科学领域:
- 兽医流行病学 兽医流行病学
- 传染病的动态传染病的动态.
- 动物卫生 动物健康
背景情况:
- 牛结核病 (bTB) 的根除受到牛群中Mycobacterium bovis (M. bovis) 感染的不完善的 ante-mortem 诊断试验的阻碍.
- 未被诊断的M. bovis感染,称为残留,亚临床,潜伏或无菌,在群体内持续存在,导致疾病传播和经济损失.
研究的目的:
- 审查M. bovis感染动态对牛的诊断测试性能的影响.
- 检查不同感染阶段如何导致未被检测到的M. bovis病例和群体分解.
主要方法:
- 对流行病学数据和诊断测试限制的文献综述.
- 分析M. bovis感染阶段及其对监测计划的影响.
主要成果:
- 传统的bTB诊断测试具有不完美的灵敏度和特异性,导致一部分受感染的动物未被检测到.
- 未被检测到的M. bovis感染可能会持续存在,通过动物的移动传播到其他群体,并使根除工作复杂化,特别是随着疾病流行率的下降.
结论:
- 感染M. bovis阶段的动态是未能诊断所有感染动物的关键因素.
- 持久的,未被检测到的感染构成长期或反复的bTB群体崩的重大风险,需要改进诊断策略.
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